• Functional studies suggested the presence of a cysLT recepto

  2020-08-10

  

  Functional studies suggested the presence of a cysLT1 receptor. We observed an LTD4-induced cytosolic calcium response, albeit one that was very weak by most standards. The magnitude of the average response was partially explained by the low percentage of 4-P-PDOT showing a very transient response.

• In the present study the expression of the

  2020-08-10

  

  In the present study, the thapsigargin of the CYP2C11 gene and the levels of its protein and activity were decreased in rats with liver insufficiency and in rats after induced dysfunction of the serotonergic system during normal liver function. Moreover, serotonergic system dysfunction during liver

• In general up to date no study has considered

  2020-08-10

  

  In general, up to date, no study has considered thermodynamic modeling to estimate the Epigallocatechin receptor of SO2 by different DESs. Since experimental measurements are time consuming and expensive, general and accurate theoretical models are vital to estimate SO2 solubilities in different DES

• br Materials and methods br Results br

  2020-08-10

  

  Materials and methods Results Discussion We have evaluated the breast cancer prevention potential of PR blockade under conditions that included exposure to progestogens that are relevant to women (progesterone and MPA) and are known to differ in their receptor-binding and down-stream effect

• Cy7 NHS ester (non-sulfonated) The need for dedicated DAPT

  2020-08-10

  

  The need for dedicated DAPT updates is well justified by the large amount of data and new information generated in the field over the past few years. As expected, the ACC/AHA and ESC updates contain large areas of overlap as well as some differences. Differences were largely explained by the differe

• 2768 Several effective strategies have been developed

  2020-08-10

  

  Several effective strategies have been developed to design activatable MR probes according to the Solomon, Bloembergen and Morgan (SBM) theory, including modulation of the number of inner-sphere water molecules (q), the rotational tumbling time (τ) and the residence lifetime of inner-sphere water mo

• TPEN The elastase induced injury model has

  2020-08-10

  

  The elastase-induced injury model has been shown to produce airspace enlargement, and increases in lung volume and compliance that are similar to those observed in human patients (Hantos et al., 2008, Hamakawa et al., 2011). Thus, this model, which has been used to study emphysema, should be adequat

• br Materials and Methods br

  2020-08-10

  

  Materials and Methods Results Discussion ROS generated by SFN target many signaling pathways involved in initiating cancer cell death (Sestili and Fimognari, 2015). For example, ROS have been shown to activate both intrinsic and extrinsic caspase cascades in prostate cancer cells (Singh et

• br Experimental Procedures br Author Contributions br Acknow

  2020-08-10

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Oxysterols came to prominence in the late 1970\'s with the oxysterol hypothesis which proposed that the suppressive effect of cholesterol on its own synthesis is mediated through oxysterols not by cholesterol itsel

• In all available E E

  2020-08-10

  

  In all available E2:E3 structures, the RING-type domain binds the E2 on a surface that is remote from the active site Cys (and therefore from the ubiquitin thioester) (Fig. 2). The non-contiguous E3-binding and active sites on the E2 imply that the role played by a RING to facilitate ubiquitin trans

• The first transcription factor TF known to interact with one

  2020-08-08

  

  The first transcription factor (TF) known to interact with one of the cis-acting GAREs is GAMYB protein, the expression of which is induced by GA in the aleurone d mannitol mg of barley (HvGAMYB) (Gubler and Jacobsen, 1992). GAMYB is an important regulator of endosperm functions during seed develop

• Oxysterols tend not to be observed in global lipidomic

  2020-08-08

  

  Oxysterols tend not to be observed in global lipidomic analysis, whether shot-gun based electrospray ionisation – mass spectrometry (ESI-MS) or liquid chromatography (LC)-MS based. This is because of their comparatively low-abundance and poor ionisation characteristics. However, methods have been de

• br Results br Discussion Human CXCR CD T

  2020-08-07

  

  Results Discussion Human CXCR5+ CD4+ T cells generated by IL-12 stimulation expressed both Tfh molecules (CD40L, ICOS, IL-21, Batf, and Bcl-6) and Th1 molecules (IFN-γ and T-bet). Therefore, as demonstrated in mice (Nakayamada et al., 2011, Pepper et al., 2011), these CXCR5+ CD4+ T cells appea

• br STAR Methods br Acknowledgments We

  2020-08-07

  

  STAR★Methods Acknowledgments We would like to thank the DNA cloning, Protein Production, DNA sequencing facility, and mass spectrometry teams of the MRC Protein Phosphorylation and Ubiquitylation Unit for their support. We would like to thank Prof. Dario Alessi, Prof. Ronald Hay, Prof. Philip

• br General mechanism of NHEJ NHEJ is an amazingly versatile

  2020-08-07

  

  General mechanism of NHEJ NHEJ is an amazingly versatile pathway that can select specific enzymes which bind to, process, and finally mediate the direct re-ligation of a wide range of DSBs including those that are complex, have incompatible ends, and contain CH5138303 synthesis damages [7], [8],

15885 records 817/1059 page Previous Next First page 上5页 816817818819820 下5页 Last page