• br Author contributions br Conflict of interests br

  2022-08-02

  

  Author contributions Conflict of interests Acknowledgements This work was supported by NIH grant DK098730 to NHM. Free fatty acids play important roles in biological processes contributing to both health and disease. As essential nutritional components, free fatty acids are utilized as b

• Salirasib Michiel S van der Heijden had full access to all

  2022-08-02

  

  Michiel S. van der Heijden had full access to all Salirasib data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Wang, Sustic, de Oliveira, van den Heuvel, Bernards, van der Heijden. Wang, Sustic, de Oliveira, van de Ven. Wang, Sustic

• Moving forward to series the energy minimized conformation o

  2022-08-02

  

  Moving forward to series , the energy minimized conformation of trabectedin receptor within the binding pocket is quite interesting. The indole-based tail guides the TZD head for a highly-favored interaction with all residues of the H-bonding triad (). In addition, an extra bonding with H449 in the

• br Introduction Before planning population based genetic ana

  2022-08-02

  

  Introduction Before planning population-based genetic analysis or GWAS, it is important to annotate the sequence of the gene because these sequences represent the major sites such as promoter and transcription factor Sabutoclax which may ultimately affect the expression of the gene. Similarly, a

• br Material and methods br Results br Discussion

  2022-07-30

  

  Material and methods Results Discussion In this paper, an HCV molecular epidemiological study was conducted in DU sentinel surveillance sites in 20 prefecture-level cities across Guangdong Province, and the different subtype distributions between IDU and NIDU were compared. Owing to the lac

• A repertoire of cytotoxic payloads is

  2022-07-30

  

  A repertoire of cytotoxic payloads is increasing; among those, MMAE has been utilized for the highly effective ADC brentuximab vedotin. However, the ADCs which utilized MMAE to target GCC in solid tumors have shown a poor efficacy suggesting that various tumor types respond differently to a given to

• br Declaration of interest br Acknowledgments br

  2022-07-30

  

  Declaration of interest Acknowledgments This work was supported by grants from the Polish National Science Centre (PRELUDIUM grant no. 2013/11/N/NZ5/00270) and the European Commission FP7 Project Beta-JUDO (grant number 279 153), European Union EIT Health project DeTecT2D, Swedish Diabetes A

• Liraglutide br Conclusion br Acknowledgements This work

  2022-07-29

  

  Conclusion Acknowledgements This work was supported by a Grant-in-Aid for challenging Exploratory Research (15K12715) and was a partly supported by Suzuken Memorial Foundation (2014). The authors would like to thank Enago (www.enago.jp) for the English language review. G protein-coupled rec

• Obestatin increased GnRH mRNA expression in the POA

  2022-07-29

  

  Obestatin increased GnRH mRNA expression in the POA, being the main place of GnRH synthesis (Goodman, 2015). Simultaneously, obestatin also caused a decrease in the GnRH mRNA expression in ME, without affecting the level of this peptide mRNA in AHA. A lack of differences observed in the mRNA level i

• br Acknowledgements This work was supported by the National

  2022-07-29

  

  Acknowledgements This work was supported by the National Key Research and Development Program of China [2017YFD0400106]; Innovation of modern Project[F18R02-03]. Introduction The Vesiculovirus genus is one of the six genera of the rhabdovirus family. The prototype vesiculovirus is vesicular s

• In conclusion we show to our knowledge

  2022-07-29

  

  In conclusion, we show, to our knowledge for the first-time, compelling evidence for functional OTR and GHSR crosstalk, which is likely via the formation of a novel OTR/GHSR heterocomplex with important downstream signalling consequences. This OTR/GHSR interaction is poised to play an important phy

• Communication through GJ channels is regulated at different

  2022-07-29

  

  Communication through GJ channels is regulated at different levels and includes GJ plaque internalization into a single cell. Those vesicles contain the membrane of both cells and th assembled Cx43. The C-terminal domain of Cx43 interacts with different peptides and proteins. However, the internaliz

• Afuresertib mg br Secretase in inflammatory diseases Secreta

  2022-07-29

  

  γ-Secretase in inflammatory diseases γ-Secretase appears to play a more important role than previously recognized in inflammatory diseases. Studies have shown that mice partially deficient in PS genes (PS1+/− PS2−/−) develop an immune system deficit in late adulthood, such as ulcerated skin or a

• Interestingly the subcellular localization of

  2022-07-29

  

  Interestingly, the subcellular localization of FBPase in hepatocytes and proximal tubule Boc-MLF australia reveals that FBPase is also able to translocate to the nucleus in these cell types. The nuclear localization of muscle-FBPase was recently reported [35]. This data corroborate our results on t

• A great number of proteins entering the

  2022-07-29

  

  A great number of proteins entering the nucleus possess a characteristic nuclear localization sequence (NLS) in their primary structure. One of such sequences is the KKKGK motif [30]. It is present in all known muscle (but not liver – except human liver) FBPase sequences (human, rabbit, rat and mous

15879 records 423/1059 page Previous Next First page 上5页 421422423424425 下5页 Last page