• DGK negatively regulated the extension of

  2019-09-02

  

  DGKδ negatively regulated the extension of long axon/neurite (Fig. 4, Fig. 5, Fig. 6). The results strongly suggest that deficiency of DGKδ induces OCD-like behavior by enhancing axon/neurite outgrowth. DGKδ positively regulates growth factor signaling (Crotty et al., 2006). Therefore, DGKδ deficien

• br Conflict statement br Introduction

  2019-09-02

  

  Conflict statement Introduction Prostate cancer (PCa) is the second most frequently diagnosed cancer and the second leading cause of cancer death in men after lung cancer [1], [2]. The incidence and mortality rate of prostate cancer are significantly higher in developed countries especially th

• br Materials and methods br Results

  2019-09-02

  

  Materials and methods Results Discussion CHIKV is an important arthropod borne virus with substantial impact on global health and cause a major viral disease that requires the development of antiviral drug to combat chikungunya disease. Virus specific proteases have particularly become an a

• Our results in the present study demonstrate that CysLT

  2019-09-02

  

  Our results in the present study demonstrate that CysLT1 mediates leukotriene-induced contraction in the fundus and suggest that both CysLT1 and CysLT2 mediate leukotriene-induced contraction in the antrum in vitro. Further studies on the effects of leukotrienes in vivo are required to elucidate the

• In contrast to PEGylated proteins which tend to have reduced

  2019-09-02

  

  In contrast to PEGylated proteins which tend to have reduced PF-06463922 in the body relative to their native counterparts, proteins conjugated to albumin tend to accumulate in certain locales in vivo. This means that albumin-based drug carrier systems have particular applications in the field of c

• Elastase belongs to chymotrypsin family of proteases and

  2019-08-30

  

  Elastase belongs to chymotrypsin family of proteases and it is responsible for the breakdown of elastin and other proteins, such as collagen and fibronectin, which are fundamental for the ECM elastic properties (Imokawa and Ishida, 2015). Misregulations of this enzyme are involved in skin ageing pro

• Recently a method for in vivo

  2019-08-30

  

  Recently, a method for in vivo photoactivation of freedom expressing PA-GFP in precise microanatomical compartments was described (Victora et al., 2010), which makes it possible to optically mark Tfh cells and track them 20 hr later (Shulman et al., 2013). Unexpectedly, it was reported that Tfh cel

• br Results br Discussion The sequence homology

  2019-08-30

  

  Results Discussion The sequence homology-based clustering of the human kinome by Manning et al. (2002) has been extremely useful to organize kinases into leukotriene receptor antagonists by sequence relationship. Since kinases are such prominent drug targets, we expect that clustering of the

• LTD and LTC cause contraction in the rat stomach and

  2019-08-30

  

  LTD4 and LTC4 cause contraction in the rat stomach and these contractions are sensitive to CysLT1 receptor antagonists (Goldenberg and Subers, 1983, Miura et al., 1992, Miyata et al., 1995). However, effects of other leukotrienes in the gastric contraction and inhibitory effects of potent, selective

• The synthesis of the required

  2019-08-30

  

  The synthesis of the required substrates is shown in (see for experimental details). Treatment of heterocycle with 5,8,11-Eicosatriynoic Acid under basic conditions afforded a mixture of the mono-substituted product (22%) and the di-substituted compound (38%) which were separated by column ch

• Lymphocyte mobility and homing is

  2019-08-30

  

  Lymphocyte mobility and homing is modulated by the chemoattractant receptor subfamily of G protein-coupled receptors (GPCRs) (Campbell et al., 2003, Rot and von Andrian, 2004). B cell migration and position are controlled to a large extent by the lymphoid chemokines CXCL13, CXCL12, CCL19, and CCL21

• Experimental studies offer a means of developing an empirica

  2019-08-30

  

  Experimental studies offer a means of developing an empirical basis for the development of forensic protocols in the investigations of specific crime types [12]. Such an evidence BS-181 and for ICST cases will help enable the identification of situations when there is likely to be recoverable DNA fr

• Previous and ongoing clinical trials have been summarized

  2019-08-30

  

  Previous and ongoing clinical trials have been summarized in a recent review (Siaw-Debrah et al., 2017). To our knowledge, there are no ongoing or completed clinical trials focusing on cytokines in ICH. Published studies have focused mainly on cytokine changes in ICH patients (summarized in Table 3)

• The small molecule d mannuronic acid M patented

  2019-08-29

  

  The small molecule β-d-mannuronic Nivolumab (M2000), patented (DE-102016113018.4), has been tested as an anti-inflammatory and a novel immunosuppressive agent in various experimental models such as animal models of immune complex glomerulonephritis, nephrotic syndrome, multiple sclerosis and rheuma

• The current study showed that the tested nonselective

  2019-08-29

  

  The current study showed that the tested nonselective COX inhibitors potentiated the neuronal (EFS) and endothelial (ACh)-dependent relaxation of rat corpus cavernosum. Indomethacin was the most effective among them in potentiating EFS-induced relaxation. Diclofenac was the most effective in potenti

15424 records 959/1029 page Previous Next First page 上5页 956957958959960 下5页 Last page