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Whereas more research is needed to identify the
2024-08-17
Whereas more research is needed to identify the precise mechanism by which FIN exerts its antidyskinetic effect, the NADP/NADPH Quantitation Colorimetric Kit that it can negatively modulate dopaminergic transmission is also supported by our previous findings. Indeed, we have previously shown that F
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The reductase family is composed of
2024-08-17
The 5α-reductase family is composed of three known isozymes, with the types I and II being the most known. Type I isozyme, which is the dominant form, can be found in the skin, liver, kidney, brain and lung. Furthermore, it has been evidenced that type I activity is several times higher in PC than i
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Acl converts cytosolic citrate CoA and ATP into acetyl
2024-08-17
Acl converts cytosolic citrate, CoA and ATP into acetyl-CoA, ADP+Pi and oxaloacetate (Fig. 1). This cytosolic enzyme is present in few Prokaryotes and in all Eukaryotes, but not in non-oleaginous yeasts [14]. Thus, this enzyme was presumed to be essential for FA synthesis [1], [13], [15]. In most mi
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br Materials and methods br Results Dried leaves
2024-08-17
Materials and methods Results Dried Gastrodin synthesis used were 48.46 g C. benghalensis, 857.98 g T. zebrina and 25.09 g T. fluminensis. The samples gave 12.9% C. benghalensis, 0.078% T. zebrina and 3.06% T. fluminensis methanol extracts. The methanol extracts were evaluated for their lipox
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As regards LEPR Sun et al
2024-08-17
As regards LEPR, Sun et al. showed that the rs1137101-223A > G polymorphism influences the effectiveness of simvastatin on plasma HDL-C levels in CHD patients [35]. In accordance with the results of García-Bermúdez et al., however, no such an association exists between leptin rs2167270 (G > A) polym
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br Summary br Introduction With
2024-08-16
Summary Introduction With readily synthetic methods and excellent chemical/physical characteristics, coumarins have received extensive attention and show great practical values in many fields, such as medicine discovery, dye chemistry, materials chemistry and so on [[1], [2], [3]]. Actually, o
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br Duality of interest br Contribution statement br Acknowle
2024-08-16
Duality of interest Contribution statement Acknowledgments Introduction Rapid, cell surface-initiated steroid actions have been reported for all major groups of steroid hormones and our understanding of membrane-mediated steroid actions has progressed rapidly over the last two decades. M
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With wide spread use of corticosteroids to combat inflammati
2024-08-16
With wide-spread use of corticosteroids to combat inflammation and allergies, even children are susceptible to corticosteroid-induced muscle wasting. Although non-steroidal SGRMs that spare muscle and bone, but have significant anti-inflammatory effects, have been preclinically developed and tested,
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br Acknowledgments This work was supported by grants from
2024-08-16
Acknowledgments This work was supported by grants from the “Agence Nationale de la Recherche” ANR-09-CESA-006 program, the Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (Anses, Project n° 2012-2-077) and the Interdisciplinary Program “Longévité et Viei
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Fmoc-L-Arg(Aloc)2-OH br The lipoxygenase pathway in diseases
2024-08-16
The 12/15-lipoxygenase pathway in diseases of the nervous system Conclusions and future perspectives Arachidonic Fmoc-L-Arg(Aloc)2-OH and other polyunsaturated fatty acids, and their lipid metabolites, play very important roles in human health and disease. This review has outlined the functio
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In pancreatic islets we found an
2024-08-16
In pancreatic islets we found an increase in protein expression of leukocyte 12/15-LO that paralleled the metabolic decline characterized by severe hyperglycemia and reduced islet numbers. Similar increase in 12/15-LO expression by Western blot was found in the control mice, which have a normal meta
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In the QFP rs T
2024-08-16
In the QFP, rs2269657-T allele showed a significant correlation with reduced plaque density in frontal cortices (Table 2), strengthening the association with amyloid pathology. The same HOSu mg region was shown to exhibit a statistically significant reduction of SREBF2 mRNA levels in rs2269657-T car
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br Conflict of interest statement br Introduction Currently
2024-08-16
Conflict of interest statement Introduction Currently, adenocarcinoma is the most common histological subtype of lung cancer. Activating mutations and translocations with a potential for targeted therapy are reported predominantly in non-smokers. ALK rearrangement is found in less than 5% of u
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In the past years the role of the CD adenosinergic
2024-08-16
In the past 10 years, the role of the CD73-adenosinergic pathway in suppression of anti-tumor immunity has increasingly been recognized [13], [14]. In this review, we discuss the latest findings dealing with the regulation of anti-tumor immunity by CD73 and adenosine. We also discuss ongoing clinica
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Patients with ADA SCID may experience
2024-08-16
Patients with ADA-SCID may experience autoimmune AEs after SCT (and/or during ERT) that are thought to be related to immune dysregulation prior to achieving complete immune reconstitution. The more common autoimmune manifestations include hemolytic anemia, hypothyroidism, and immune thrombocytopenia
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